CATH Domain 1iyvA00

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.40	Beta Barrel
	2.40.50	OB fold (Dihydrolipoamide Acetyltransferase, E2P)
	2.40.50.100	RNA polymerase II/Efflux pump adaptor protein, barrel-sandwich hybrid domain

Domain Context

CATH Clusters

Superfamily	2.40.50.100
Functional Family

Enzyme Information

2.3.1.12

Dihydrolipoyllysine-residue acetyltransferase.

based on mapping to UniProt P10802

Acetyl-CoA + enzyme N(6)-(dihydrolipoyl)lysine = CoA + enzyme N(6)- (S-acetyldihydrolipoyl)lysine.

-!- A multimer (24-mer or 60-mer, depending on the source) of this enzyme forms the core of the pyruvate dehydrogenase multienzyme complex, and binds tightly both EC 1.2.4.1 and EC 1.8.1.4. -!- The lipoyl group of this enzyme is reductively acetylated by EC 1.2.4.1, and the only observed direction catalyzed by EC 2.3.1.12 is that where the acetyl group is passed to coenzyme A.

UniProtKB Entries (1)

P10802

ODP2_AZOVI

Azotobacter vinelandii

Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex

PDB Structure

PDB	1IYV
External Links	PDBSum Proteopedia
Method	SOLUTION NMR
Organism
Primary Citation	Three-dimensional structure in solution of the N-terminal lipoyl domain of the pyruvate dehydrogenase complex from Azotobacter vinelandii. Berg, A., Vervoort, J., de Kok, A. Eur.J.Biochem.