CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.50 | 3-Layer(bba) Sandwich |
|
3.50.50 | FAD/NAD(P)-binding domain |
|
3.50.50.60 | FAD/NAD(P)-binding domain |
Domain Context
CATH Clusters
| Superfamily | FAD/NAD(P)-binding domain |
| Functional Family | p-hydroxybenzoate hydroxylase |
Enzyme Information
| 1.14.13.2 |
4-hydroxybenzoate 3-monooxygenase.
based on mapping to UniProt P20586
4-hydroxybenzoate + NADPH + O(2) = protocatechuate + NADP(+) + H(2)O.
-!- Most enzymes from Pseudomonas are highly specific for NAD(P)H (cf. EC 1.14.13.33).
|
UniProtKB Entries (1)
| P20586 |
PHHY_PSEAE
Pseudomonas aeruginosa PAO1
P-hydroxybenzoate hydroxylase
|
PDB Structure
| PDB | 1IUV |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
pH-dependent structural changes in the active site of p-hydroxybenzoate hydroxylase point to the importance of proton and water movements during catalysis.
Biochemistry
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