CATH Domain 1is8A02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.1130	GTP Cyclohydrolase I, domain 2
	3.30.1130.10	GTP cyclohydrolase I, C-terminal domain/NADPH-dependent 7-cyano-7-deazaguanine reductase, N-terminal domain

Domain Context

CATH Clusters

Superfamily	3.30.1130.10
Functional Family	GTP cyclohydrolase 1

Enzyme Information

3.5.4.16

GTP cyclohydrolase I.

based on mapping to UniProt P22288

GTP + H(2)O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3- trihydroxypropyl)-dihydropteridine triphosphate.

-!- The reaction involves hydrolysis of two C-N bonds and isomerization of the pentose unit; the recyclization may be non-enzymic. -!- Involved in the de novo synthesis of tetrahydrobiopterin from GTP, with the other enzymes involved being EC 1.1.1.153 and EC 4.2.3.12.

UniProtKB Entries (1)

P70552

GFRP_RAT

Rattus norvegicus

GTP cyclohydrolase 1 feedback regulatory protein

PDB Structure

PDB	1IS8
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Crystal structure of the stimulatory complex of GTP cyclohydrolase I and its feedback regulatory protein GFRP. Maita, N., Okada, K., Hatakeyama, K., Hakoshima, T. Proc.Natl.Acad.Sci.USA