CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.10 | Orthogonal Bundle |
|
1.10.286 | GTP Cyclohydrolase I; Chain A, domain 1 |
|
1.10.286.10 | GTP cyclohydrolase I, N-terminal domain |
Domain Context
CATH Clusters
| Superfamily | 1.10.286.10 |
| Functional Family | GTP cyclohydrolase 1 |
Enzyme Information
| 3.5.4.16 |
GTP cyclohydrolase I.
based on mapping to UniProt P22288
GTP + H(2)O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3- trihydroxypropyl)-dihydropteridine triphosphate.
-!- The reaction involves hydrolysis of two C-N bonds and isomerization of the pentose unit; the recyclization may be non-enzymic. -!- Involved in the de novo synthesis of tetrahydrobiopterin from GTP, with the other enzymes involved being EC 1.1.1.153 and EC 4.2.3.12.
|
UniProtKB Entries (1)
| P70552 |
GFRP_RAT
Rattus norvegicus
GTP cyclohydrolase 1 feedback regulatory protein
|
PDB Structure
| PDB | 1IS8 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Crystal structure of the stimulatory complex of GTP cyclohydrolase I and its feedback regulatory protein GFRP.
Proc.Natl.Acad.Sci.USA
|
