CATH Domain 1iq6A00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.10	Roll
	3.10.129	Thiol Ester Dehydrase; Chain A
	3.10.129.10	Hotdog Thioesterase

Domain Context

CATH Clusters

Superfamily	Hotdog Thioesterase
Functional Family	MaoC domain protein dehydratase

Enzyme Information

4.2.1.119

Enoyl-CoA hydratase 2.

based on mapping to UniProt O32472

(3R)-3-hydroxyacyl-CoA = (2E)-2-enoyl-CoA + H(2)O.

-!- This enzyme catalyzes a hydration step in peroxisomal beta-oxidation. -!- The human multifunctional enzyme type 2 (MFE-2) is a 79000 Da enzyme composed of three functional units: (3R)-hydroxyacyl-CoA dehydrogenase, 2-enoyl-CoA hydratase 2 and sterol carrier protein 2-like units. -!- The enzymes from Aeromonas caviae and Arabidopsis thaliana are monofunctional enzymes. -!- 2-enoyl-CoA hydratase 3 from Candida tropicalis is a part from multifunctional enzyme type 2.

UniProtKB Entries (1)

O32472

PHAJ_AERCA

Aeromonas caviae

(R)-specific enoyl-CoA hydratase

PDB Structure

PDB	1IQ6
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Crystal structure of the (R)-specific enoyl-CoA hydratase from Aeromonas caviae involved in polyhydroxyalkanoate biosynthesis Hisano, T., Tsuge, T., Fukui, T., Iwata, T., Miki, K., Doi, Y. J.Biol.Chem.