CATH Classification
Domain Context
CATH Clusters
| Superfamily | N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 |
| Functional Family | 3-hydroxybutyryl-CoA dehydrogenase FadB2 |
Enzyme Information
| 1.1.1.35 |
3-hydroxyacyl-CoA dehydrogenase.
based on mapping to UniProt Q16836
(S)-3-hydroxyacyl-CoA + NAD(+) = 3-oxoacyl-CoA + NADH.
-!- Also oxidizes S-3-hydroxyacyl-N-acylthioethanolamine and S-3- hydroxyacylhydrolipoate. -!- Some enzymes act, more slowly, with NADP(+). -!- Broad specificity to acyl chain-length (cf. EC 1.1.1.211).
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UniProtKB Entries (1)
| Q16836 |
HCDH_HUMAN
Homo sapiens
Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial
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PDB Structure
| PDB | 1IL0 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Glutamate 170 of human l-3-hydroxyacyl-CoA dehydrogenase is required for proper orientation of the catalytic histidine and structural integrity of the enzyme.
J.Biol.Chem.
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