CATH Classification

Domain Context

CATH Clusters

Superfamily Aldolase class I
Functional Family Indole-3-glycerol phosphate synthase

Enzyme Information

4.1.1.48
Indole-3-glycerol-phosphate synthase.
based on mapping to UniProt Q06121
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C- (3-indolyl)-glycerol 3-phosphate + CO(2) + H(2)O.
-!- In some organisms, this enzyme is part of a multifunctional protein together with one or more components of the system for biosynthesis of tryptophan (EC 2.4.2.18, EC 4.1.3.27, EC 4.2.1.20 and EC 5.3.1.24).

UniProtKB Entries (1)

Q06121
TRPC_SACS2
Saccharolobus solfataricus P2
Indole-3-glycerol phosphate synthase

PDB Structure

PDB 1IGS
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
2.0 A structure of indole-3-glycerol phosphate synthase from the hyperthermophile Sulfolobus solfataricus: possible determinants of protein stability.
Hennig, M., Darimont, B., Sterner, R., Kirschner, K., Jansonius, J.N.
Structure
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