CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
2 | Mainly Beta |
|
2.40 | Beta Barrel |
|
2.40.50 | OB fold (Dihydrolipoamide Acetyltransferase, E2P) |
|
2.40.50.170 | Cysteine proteinases. Chain C |
Domain Context
CATH Clusters
| Superfamily | Cysteine proteinases. Chain C |
| Functional Family | Cathepsin L1 |
Enzyme Information
| 3.4.22.15 |
Cathepsin L.
based on mapping to UniProt P07711
Specificity close to that of papain. As compared to cathepsin B, cathepsin L exhibits higher activity toward protein substrates, but has little activity on Z-Arg-Arg-NHMec, and no peptidyl-dipeptidase activity.
-!- A lysosomal enzyme that is readily inhibited by the diazomethane inhibitor Z-Phe-Phe-CHN(2) or the epoxide inhibitor E-64. -!- Belongs to peptidase family C1.
|
UniProtKB Entries (1)
| P07711 |
CATL1_HUMAN
Homo sapiens
Cathepsin L1
|
PDB Structure
| PDB | 1ICF |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Crystal structure of MHC class II-associated p41 Ii fragment bound to cathepsin L reveals the structural basis for differentiation between cathepsins L and S.
EMBO J.
|
