CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
2 | Mainly Beta |
|
2.40 | Beta Barrel |
|
2.40.10 | Thrombin, subunit H |
|
2.40.10.10 | Trypsin-like serine proteases |
Domain Context
CATH Clusters
| Superfamily | Trypsin-like serine proteases |
| Functional Family | Complement factor D |
Enzyme Information
| 3.4.21.79 |
Granzyme B.
based on mapping to UniProt P10144
Preferential cleavage: -Asp-|-Xaa- >> -Asn-|-Xaa- > -Met-|-Xaa-, -Ser-|-Xaa-.
-!- From cytotoxic T lymphocyte granules. -!- Belongs to peptidase family S1.
|
UniProtKB Entries (1)
| P10144 |
GRAB_HUMAN
Homo sapiens
Granzyme B
|
PDB Structure
| PDB | 1IAU |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Spodoptera |
| Primary Citation |
The three-dimensional structure of human granzyme B compared to caspase-3, key mediators of cell death with cleavage specificity for aspartic acid in P1.
Chem.Biol.
|
