CATH Classification
Level | CATH Code | Description |
---|---|---|
3 | Alpha Beta | |
3.40 | 3-Layer(aba) Sandwich | |
3.40.430 | Dihydrofolate Reductase, subunit A | |
3.40.430.10 | Dihydrofolate Reductase, subunit A |
Domain Context
CATH Clusters
Superfamily | Dihydrofolate Reductase, subunit A |
Functional Family | Dihydrofolate reductase |
Enzyme Information
1.5.1.3 |
Dihydrofolate reductase.
based on mapping to UniProt P22906
5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + NADPH.
-!- The enzyme from animals and some micro-organisms also slowly reduces folate to 5,6,7,8-tetrahydrofolate. -!- Formerly EC 1.5.1.4.
|
UniProtKB Entries (1)
P22906 |
DYR_CANAX
Candida albicans
Dihydrofolate reductase
|
PDB Structure
PDB | 1IA2 |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | Escherichia |
Primary Citation |
X-ray Crystal Structures of Candida albicans Dihydrofolate Reductase: High Resolution Ternary Complexes in Which the Dihydronicotinamide Moiety of NADPH is Displaced by an inhibitor
J.Med.Chem.
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