CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.20 | Up-down Bundle |
|
1.20.1050 | Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 |
|
1.20.1050.40 | Endopeptidase. Chain P; domain 1 |
Domain Context
CATH Clusters
| Superfamily | Endopeptidase. Chain P; domain 1 |
| Functional Family | Thimet oligopeptidase 1 |
Enzyme Information
| 3.4.24.16 |
Neurolysin.
based on mapping to UniProt P42676
Preferential cleavage in neurotensin: 10-Pro-|-Tyr-11.
-!- No absolute requirement for a prolyl bond; the enzyme acts on some peptides, such as dynorphin 1-8, that do not contain proline, and does not act on some others that do. -!- Belongs to peptidase family M3.
|
UniProtKB Entries (1)
| P42676 |
NEUL_RAT
Rattus norvegicus
Neurolysin, mitochondrial
|
PDB Structure
| PDB | 1I1I |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Structure of neurolysin reveals a deep channel that limits substrate access.
Proc.Natl.Acad.Sci.USA
|
