CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.20 | Alpha-Beta Barrel |
|
3.20.110 | 7-stranded beta/alpha barrel |
|
3.20.110.10 | Glycoside hydrolase 38, N terminal domain |
Domain Context
CATH Clusters
| Superfamily | Glycoside hydrolase 38, N terminal domain |
| Functional Family | Alpha-mannosidase |
Enzyme Information
| 3.2.1.114 |
Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase.
based on mapping to UniProt Q24451
Man(5)GlcNAc(3)-[protein] + 2 H(2)O = Man(3)GlcNAc(3)-[protein] + 2 alpha-D-mannopyranose.
-!- The enzyme, found in plants and animals, participates in the processing of N-glycans in the Golgi apparatus. -!- It removes two mannosyl residues, one linked by alpha-1,3 linkage, and the other linked by alpha-1,6 linkage, both of which are removed by the same catalytic site. -!- The enzyme is sensitive to swainsonine.
|
UniProtKB Entries (1)
| Q24451 |
MAN2_DROME
Drosophila melanogaster
Alpha-mannosidase 2
|
PDB Structure
| PDB | 1HXK |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Drosophila |
| Primary Citation |
Structure of Golgi alpha-mannosidase II: a target for inhibition of growth and metastasis of cancer cells.
EMBO J.
|
