CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.20 | Alpha-Beta Barrel |
|
3.20.20 | TIM Barrel |
|
3.20.20.100 | NADP-dependent oxidoreductase domain |
Domain Context
CATH Clusters
| Superfamily | NADP-dependent oxidoreductase domain |
| Functional Family | Oxidoreductase, aldo/keto reductase family |
Enzyme Information
| 1.1.1.346 |
2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming).
based on mapping to UniProt P06632
2-dehydro-L-gulonate + NADP(+) = 2,5-didehydro-D-gluconate + NADPH.
-!- The enzyme is involved in ketogluconate metabolism, and catalyzes the reaction in vivo in the reverse direction to that shown. -!- It is used in the commercial microbial production of ascorbate. -!- cf. EC 1.1.1.274.
|
UniProtKB Entries (1)
| P06632 |
DKGA_CORSC
Corynebacterium sp. ATCC 31090
2,5-diketo-D-gluconic acid reductase A
|
PDB Structure
| PDB | 1HW6 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Spodoptera |
| Primary Citation |
Structural assembly of the active site in an aldo-keto reductase by NADPH cofactor.
J.Mol.Biol.
|