CATH Domain 1hw4A00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.572	Thymidylate Synthase; Chain A
	3.30.572.10	Thymidylate synthase/dCMP hydroxymethylase domain

Domain Context

CATH Clusters

Superfamily	Thymidylate synthase/dCMP hydroxymethylase domain
Functional Family	Possible thymidylate synthase

Enzyme Information

2.1.1.45

Thymidylate synthase.

based on mapping to UniProt P04818

5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP.

UniProtKB Entries (1)

TYSY_HUMAN

Homo sapiens

Thymidylate synthase

PDB Structure

PDB	1HW4
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Structure of human thymidylate synthase suggests advantages of chemotherapy with noncompetitive inhibitors. Phan, J., Steadman, D.J., Koli, S., Ding, W.C., Minor, W., Dunlap, R.B., Berger, S.H., Lebioda, L. J.Biol.Chem.