CATH Domain 1hu9A04

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.10	Roll
	3.10.450	Nuclear Transport Factor 2; Chain: A,
	3.10.450.60

Domain Context

CATH Clusters

Superfamily	3.10.450.60
Functional Family	Lipoxygenase

Enzyme Information

1.13.11.58

Linoleate 9S-lipoxygenase.

based on mapping to UniProt P09186

Linoleate + O(2) = (9S,10E,12Z)-9-hydroperoxy-10,12-octadecadienoate.

-!- A common plant lipoxygenase that oxidizes linoleate and alpha- linolenate, the two most common polyunsaturated fatty acids in plants, by inserting molecular oxygen at the C(9) position with (S)- configuration. -!- The enzyme plays a physiological role during the early stages of seedling growth. -!- The enzyme from Arabidopsis thaliana shows comparable activity toward linoleate and linolenate. -!- EC 1.13.11.12 catalyzes a similar reaction at another position of these fatty acids.

UniProtKB Entries (1)

P09186

LOX3_SOYBN

Glycine max

Seed linoleate 9S-lipoxygenase-3

PDB Structure

PDB	1HU9
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structure of curcumin in complex with lipoxygenase and its significance in cancer. Skrzypczak-Jankun, E., Zhou, K., McCabe, N.P., Selman, S.H., Jankun, J. INT.J.MOL.MED.