CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
6 | Special |
|
6.10 | Helix non-globular |
|
6.10.140 | Helix Hairpins |
|
6.10.140.60 |
Domain Context
CATH Clusters
| Superfamily | 6.10.140.60 |
| Functional Family |
Enzyme Information
| 3.4.23.3 |
Gastricsin.
based on mapping to UniProt P20142
More restricted specificity than pepsin A, but shows preferential cleavage at Tyr-|-Xaa bonds. High activity on hemoglobin.
-!- Formed from progastricsin, apparently in the gastric juice of most vertebrates. -!- In addition to the fundus, progastricsin is also secreted in antrum and proximal duodenum. -!- Seminal plasma contains a zymogen that is immunologically identical with progastricsin. -!- Belongs to peptidase family A1. -!- Formerly EC 3.4.4.22.
|
UniProtKB Entries (1)
| P20142 |
PEPC_HUMAN
Homo sapiens
Gastricsin
|
PDB Structure
| PDB | 1HTR |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Crystal and molecular structures of human progastricsin at 1.62 A resolution.
J.Mol.Biol.
|