CATH Domain 1hjrC00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.420	Nucleotidyltransferase; domain 5
	3.30.420.10	Ribonuclease H-like superfamily/Ribonuclease H

Domain Context

CATH Clusters

Superfamily	Ribonuclease H-like superfamily/Ribonuclease H
Functional Family	Crossover junction endodeoxyribonuclease RuvC

Enzyme Information

3.1.22.4

Crossover junction endodeoxyribonuclease.

based on mapping to UniProt P0A814

Endonucleolytic cleavage at a junction such as a reciprocal single- stranded crossover between two homologous DNA duplexes (Holliday junction).

-!- The enzyme from Saccharomyces cerevisiae has no endonuclease or exonuclease activity on single-stranded or double-stranded DNA molecules that do not contain Holliday junctions.

UniProtKB Entries (1)

P0A814

RUVC_ECOLI

Escherichia coli K-12

Crossover junction endodeoxyribonuclease RuvC

PDB Structure

PDB	1HJR
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Atomic structure of the RuvC resolvase: a holliday junction-specific endonuclease from E. coli. Ariyoshi, M., Vassylyev, D.G., Iwasaki, H., Nakamura, H., Shinagawa, H., Morikawa, K. Cell(Cambridge,Mass.)