CATH Classification

Domain Context

CATH Clusters

Superfamily B-lactam Antibiotic, Isopenicillin N Synthase; Chain
Functional Family

Enzyme Information

1.14.20.1
Deacetoxycephalosporin-C synthase.
based on mapping to UniProt P18548
Penicillin N + 2-oxoglutarate + O(2) = deacetoxycephalosporin C + succinate + CO(2) + H(2)O.
-!- Forms part of the penicillin biosynthesis pathway.

UniProtKB Entries (1)

P18548
CEFE_STRC2
Streptomyces clavuligerus ATCC 27064
Deacetoxycephalosporin C synthase

PDB Structure

PDB 1HJF
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Alteration of the 2-Oxoacid Cosubstrate Selectivity in Deacetoxycephalosporin C Synthase: The Role of Arginine-258
Lee, H.J., Lloyd, M.D., Harlos, K., Clifton, I.J., Baldwin, J.E., Schofield, C.J.
J.Biol.Chem.
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