CATH Domain 1h93A02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.360	Dihydrodipicolinate Reductase; domain 2
	3.30.360.10	Dihydrodipicolinate Reductase; domain 2

Domain Context

CATH Clusters

Superfamily	Dihydrodipicolinate Reductase; domain 2
Functional Family

Enzyme Information

1.1.1.363

Glucose-6-phosphate dehydrogenase (NAD(P)(+)).

based on mapping to UniProt P11411

D-glucose 6-phosphate + NAD(P)(+) = 6-phospho-D-glucono-1,5-lactone + NAD(P)H.

-!- The enzyme catalyzes a step of the pentose phosphate pathway. -!- The enzyme from the Gram-positive bacterium Leuconostoc mesenteroides prefers NADP(+) while the enzyme from the Gram-negative bacterium Gluconacetobacter xylinus prefers NAD(+). -!- Cf. EC 1.1.1.49 and EC 1.1.1.388.

UniProtKB Entries (1)

P11411

G6PD_LEUME

Leuconostoc mesenteroides

Glucose-6-phosphate 1-dehydrogenase

PDB Structure

PDB	1H93
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Nadp+ and Nad+ Binding to the Dual Coenzyme Specific Enzyme Leuconostoc Mesenteroides Glucose 6-Phosphate Dehydrogenase: Different Interdomain Hinge Angles are Seen in Different Binary and Ternary Complexes Naylor, C.E., Gover, S., Basak, A.K., Cosgrove, M.S., Levy, H.R., Adams, M.J. Acta Crystallogr.,Sect.D