CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
2 | Mainly Beta |
|
2.60 | Sandwich |
|
2.60.120 | Jelly Rolls |
|
2.60.120.330 | B-lactam Antibiotic, Isopenicillin N Synthase; Chain |
Domain Context
CATH Clusters
| Superfamily | B-lactam Antibiotic, Isopenicillin N Synthase; Chain |
| Functional Family | Flavonol synthase |
Enzyme Information
| 1.14.20.4 |
Anthocyanidin synthase.
based on mapping to UniProt Q96323
A (2R,3S,4S)-leucoanthocyanidin + 2-oxoglutarate + O(2) = an anthocyanidin + succinate + CO(2) + 2 H(2)O.
-!- Is involved in the pathway by which many flowering plants make anthocyanin flower pigments (glycosylated anthocyandins). -!- Hydroxylates the C-3 carbon, followed by a trans diaxial elimination, forming a C-2,C-3 enol. -!- The product loses a second water molecule to form anthocyanidins. -!- When assayed in vitro, non-enzymic epimerization of the product can lead to formation of dihydroflavanols. -!- Thus when the substrate is leucocyanidin, a mixture of (+)-taxifolin and (+)-epitaxifolin are formed. -!- The enzyme can also oxidize the formed (+)-taxifolin to quercetin (cf. EC 1.14.20.6). -!- Formerly EC 1.14.11.19.
|
UniProtKB Entries (1)
| Q96323 |
LDOX_ARATH
Arabidopsis thaliana
Leucoanthocyanidin dioxygenase
|
PDB Structure
| PDB | 1GP4 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structure and Mechanism of Anthocyanidin Synthase from Arabidopsis Thaliana.
Structure
|
