CATH Domain 1gmyA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.70	Cathepsin B; Chain A
	3.90.70.10	Cysteine proteinases

Domain Context

CATH Clusters

Superfamily	Cysteine proteinases
Functional Family	Cathepsin B

Enzyme Information

3.4.22.1

Cathepsin B.

based on mapping to UniProt P07858

Hydrolysis of proteins with broad specificity for peptide bonds. Preferentially cleaves -Arg-Arg-|-Xaa bonds in small molecule substrates (thus differing from cathepsin L). In addition to being an endopeptidase, shows peptidyl-dipeptidase activity, liberating C-terminal dipeptides.

-!- An intracellular (lysosomal) enzyme. -!- Belongs to peptidase family C1.

UniProtKB Entries (1)

P07858

CATB_HUMAN

Homo sapiens

Cathepsin B

PDB Structure

PDB	1GMY
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Identification of Dipeptidyl Nitriles as Potent and Selective Inhibitors of Cathepsin B Through Structure-Based Drug Design Greenspan, P.D., Clark, K.L., Tommasi, R.A., Cowen, S.D., Mcquire, L.W., Farley, D.L., Van Duzer, J.H., Goldberg, R.L., Zhou, H., Du, Z., Fitt, J.J., Coppa, D.E., Fang, Z., Macchia, W., Zhu, L., Capparelli, M.P., Goldstein, R., Wigg, A.M., Doughty, J.R., S Bohacek, R., Knap, A.K. J.Med.Chem.