CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.10 | Orthogonal Bundle |
|
1.10.460 | Topoisomerase I; domain 2 |
|
1.10.460.10 | Topoisomerase I, domain 2 |
Domain Context
CATH Clusters
| Superfamily | Topoisomerase I, domain 2 |
| Functional Family |
Enzyme Information
| 3.6.4.12 |
DNA helicase.
based on mapping to UniProt O29238
ATP + H(2)O = ADP + phosphate.
-!- DNA helicases utilize the energy from ATP hydrolysis to unwind double-stranded DNA. -!- Some of them unwind duplex DNA with a 3' to 5' polarity (1,3,5,8), other show 5' to 3' polarity (10,11,12,13) or unwind DNA in both directions (14,15). -!- Some helicases unwind DNA as well as RNA (4,9). -!- May be identical with EC 3.6.4.13 (RNA helicase).
|
| 5.6.2.3 |
DNA topoisomerase (ATP-hydrolyzing).
based on mapping to UniProt O29238
ATP-dependent breakage, passage and rejoining of double-stranded DNA.
-!- The enzyme can introduce negative superhelical turns into double- stranded circular DNA. -!- One unit has nicking-closing activity, and another catalyzes super- twisting and hydrolysis of ATP (cf. EC 5.6.2.2). -!- Formerly EC 5.99.1.3.
|
UniProtKB Entries (1)
| O29238 |
RGYR_ARCFU
Archaeoglobus fulgidus DSM 4304
Reverse gyrase
|
PDB Structure
| PDB | 1GL9 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Crystal Structure of Reverse Gyrase: Insights Into the Positive Supercoiling of DNA.
Embo J.
|