CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.10 | Orthogonal Bundle |
|
1.10.439 | Penicillin Amidohydrolase; domain 1 |
|
1.10.439.10 | Penicillin Amidohydrolase, domain 1 |
Domain Context
CATH Clusters
| Superfamily | Penicillin Amidohydrolase, domain 1 |
| Functional Family |
Enzyme Information
| 3.5.1.93 |
Glutaryl-7-aminocephalosporanic-acid acylase.
based on mapping to UniProt P07662
(7R)-7-(4-carboxybutanamido)cephalosporanate + H(2)O = (7R)-7- aminocephalosporanate + glutarate.
-!- Forms 7-aminocephalosporanic acid, a key intermediate in the synthesis of cephem antibiotics. -!- It reacts only weakly with cephalosporin C.
|
UniProtKB Entries (1)
| P07662 |
G7AC_PSEU7
Pseudomonas sp. SY-77-1
Glutaryl-7-aminocephalosporanic-acid acylase
|
PDB Structure
| PDB | 1GK0 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structure-Based Prediction of Modifications in Glutarylamidase to Allow Single-Step Enzymatic Production of 7-Aminocephalosporanic Acid from Cephalosporin C.
Protein Sci.
|
