CATH Domain 1gj4H02

Level	CATH Code	Description
	2	Mainly Beta
	2.40	Beta Barrel
	2.40.10	Thrombin, subunit H
	2.40.10.10	Trypsin-like serine proteases

Superfamily	Trypsin-like serine proteases
Functional Family	Prothrombin

3.4.21.5

Thrombin.

based on mapping to UniProt P00734

Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.

-!- More selective than trypsin and plasmin. -!- Belongs to peptidase family S1. -!- Formerly EC 3.4.4.13.

P00734	THRB_HUMAN Homo sapiens Prothrombin
P28504	HIR2_HIRME Hirudo medicinalis Hirudin-2

PDB	1GJ4
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Engineering inhibitors highly selective for the S1 sites of Ser190 trypsin-like serine protease drug targets. Katz, B.A., Sprengeler, P.A., Luong, C., Verner, E., Elrod, K., Kirtley, M., Janc, J., Spencer, J.R., Breitenbucher, J.G., Hui, H., McGee, D., Allen, D., Martelli, A., Mackman, R.L. Chem.Biol.