CATH Domain 1gg4A03

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.1390	Udp-n-acetylmuramoylalanyl-d-glutamate--2,6- Diaminopimelate Ligase; Chain: A, domain 1
	3.40.1390.10	MurE/MurF, N-terminal domain

Domain Context

CATH Clusters

Superfamily	MurE/MurF, N-terminal domain
Functional Family	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase

Enzyme Information

6.3.2.10

UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase.

based on mapping to UniProt P11880

ATP + UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-L-lysine + D-alanyl- D-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-gamma-D- glutamyl-L-lysyl-D-alanyl-D-alanine.

-!- Involved with EC 6.3.2.4, EC 6.3.2.7 or EC 6.3.2.13, EC 6.3.2.8 and EC 6.3.2.9 in the synthesis of a cell-wall peptide. -!- Also catalyzes the reaction when the C-terminal residue of the tripeptide is meso-2,4-diaminoheptanedioate (acylated at its L-center), linking the D-Ala--D-Ala to the carboxy group of the L-center. -!- Formerly EC 6.3.2.15.

UniProtKB Entries (1)

P11880

MURF_ECOLI

Escherichia coli K-12

UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase

PDB Structure

PDB	1GG4
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Crystal structure of Escherichia coli UDPMurNAc-tripeptide d-alanyl-d-alanine-adding enzyme (MurF) at 2.3 A resolution. Yan, Y., Munshi, S., Leiting, B., Anderson, M.S., Chrzas, J., Chen, Z. J.Mol.Biol.