CATH Domain 1g99A01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.420	Nucleotidyltransferase; domain 5
	3.30.420.40	ATPase, nucleotide binding domain

Domain Context

CATH Clusters

Superfamily	3.30.420.40
Functional Family

Enzyme Information

2.7.2.1

Acetate kinase.

based on mapping to UniProt P38502

ATP + acetate = ADP + acetyl phosphate.

-!- While purified enzyme from Escherichia coli is specific for acetate, others have found that the enzyme can also use propanoate as a substrate, but more slowly. -!- Acetate can be converted into the key metabolic intermediate acetyl- CoA by coupling acetate kinase with EC 2.3.1.8. -!- Both this enzyme and EC 2.7.2.15 play important roles in the production of propanoate.

UniProtKB Entries (1)

P38502

ACKA_METTE

Methanosarcina thermophila

Acetate kinase

PDB Structure

PDB	1G99
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Urkinase: structure of acetate kinase, a member of the ASKHA superfamily of phosphotransferases. Buss, K.A., Cooper, D.R., Ingram-Smith, C., Ferry, J.G., Sanders, D.A., Hasson, M.S. J.Bacteriol.