CATH Domain 1g0vA02

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.40	Beta Barrel
	2.40.70	Cathepsin D, subunit A; domain 1
	2.40.70.10	Acid Proteases

Domain Context

CATH Clusters

Superfamily	Acid Proteases
Functional Family	Vacuolar aspartic proteinase

Enzyme Information

3.4.23.25

Saccharopepsin.

based on mapping to UniProt P07267

Hydrolysis of proteins with broad specificity for peptide bonds. Cleaves -Leu-Leu-|-Val-Tyr- bond in a synthetic substrate. Does not act on esters of Tyr or Arg.

-!- Located in the vacuole. -!- Belongs to peptidase family A1. -!- Formerly EC 3.4.4.17, EC 3.4.23.6 and EC 3.4.23.8.

UniProtKB Entries (1)

P07267

CARP_YEAST

Saccharomyces cerevisiae S288C

Saccharopepsin

PDB Structure

PDB	1G0V
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	The potency and specificity of the interaction between the IA3 inhibitor and its target aspartic proteinase from Saccharomyces cerevisiae. Phylip, L.H., Lees, W.E., Brownsey, B.G., Bur, D., Dunn, B.M., Winther, J.R., Gustchina, A., Li, M., Copeland, T., Wlodawer, A., Kay, J. J.Biol.Chem.