CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.10 | Orthogonal Bundle |
|
1.10.10 | Arc Repressor Mutant, subunit A |
|
1.10.10.10 | Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain |
Domain Context
CATH Clusters
| Superfamily | Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain |
| Functional Family |
Enzyme Information
| 2.1.1.65 |
Licodione 2'-O-methyltransferase.
based on mapping to UniProt P93324
S-adenosyl-L-methionine + licodione = S-adenosyl-L-homocysteine + 2'-O- methyllicodione.
-!- As well as licodione (1-(2,4-dihydroxyphenyl)-3-(4-hydroxyphenyl)- 1,3-propanedione), the 2''-hydroxy-derivative and isoliquiritigenin can act as acceptors, more slowly.
|
| 2.1.1.154 |
Isoliquiritigenin 2'-O-methyltransferase.
based on mapping to UniProt P93324
S-adenosyl-L-methionine + isoliquiritigenin = S-adenosyl-L-homocysteine + 2'-O-methylisoliquiritigenin.
-!- Not identical to EC 2.1.1.65. -!- While EC 2.1.1.154 can use licodione as a substrate, EC 2.1.1.65 cannot use isoliquiritigenin as a substrate.
|
UniProtKB Entries (1)
| P93324 |
CHOMT_MEDSA
Medicago sativa
Isoliquiritigenin 2'-O-methyltransferase
|
PDB Structure
| PDB | 1FP1 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Structures of two natural product methyltransferases reveal the basis for substrate specificity in plant O-methyltransferases.
Nat.Struct.Biol.
|
