CATH Domain 1fkdA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.10	Roll
	3.10.50	Chitinase A; domain 3
	3.10.50.40

Domain Context

CATH Clusters

Superfamily	3.10.50.40
Functional Family	Peptidyl-prolyl cis-trans isomerase FKBP1A

Enzyme Information

5.2.1.8

Peptidylprolyl isomerase.

based on mapping to UniProt P62942

Peptidylproline (omega=180) = peptidylproline (omega=0).

-!- The first type of this enzyme found proved to be the protein cyclophilin, which binds the immunosuppressant cyclosporin A. -!- Other distinct families of the enzyme exist, one being FK-506 binding proteins (FKBP) and another that includes parvulin from Escherichia coli. -!- The three families are structurally unrelated and can be distinguished by being inhibited by cyclosporin A, FK-506 and 5-hydroxy-1,4-naphthoquinone, respectively.

UniProtKB Entries (1)

P62942

FKB1A_HUMAN

Homo sapiens

Peptidyl-prolyl cis-trans isomerase FKBP1A

PDB Structure

PDB	1FKD
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	FK-506-binding protein: three-dimensional structure of the complex with the antagonist L-685,818. Becker, J.W., Rotonda, J., McKeever, B.M., Chan, H.K., Marcy, A.I., Wiederrecht, G., Hermes, J.D., Springer, J.P. J.Biol.Chem.