CATH Classification
Level | CATH Code | Description |
---|---|---|
2 | Mainly Beta | |
2.20 | Single Sheet | |
2.20.25 | N-terminal domain of TfIIb | |
2.20.25.90 | ADC-like domains |
Domain Context
CATH Clusters
Superfamily | ADC-like domains |
Functional Family | Formate dehydrogenase subunit alpha |
Enzyme Information
1.17.1.9 |
Formate dehydrogenase.
based on mapping to UniProt P07658
Formate + NAD(+) = CO(2) + NADH.
-!- The enzyme from most aerobic organisms is devoid of redox-active centers but that from the proteobacterium Methylosinus trichosporium contains iron-sulfur centers, flavin and a molybdenum center. -!- Together with EC 1.12.1.2, forms a system previously known as formate hydrogenlyase. -!- Formerly EC 1.2.1.2.
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1.17.99.7 |
Formate dehydrogenase (acceptor).
based on mapping to UniProt P07658
Formate + acceptor = CO(2) + reduced acceptor.
-!- Formate dehydrogenase H is a cytoplasmic enzyme that oxidizes formate without oxygen transfer, transferring electrons to a hydrogenase. -!- The two enzymes form the formate-hydrogen lyase complex. -!- The enzyme contains a selenocysteine residue. -!- Formerly EC 1.1.99.33.
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UniProtKB Entries (1)
P07658 |
FDHF_ECOLI
Escherichia coli K-12
Formate dehydrogenase H
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PDB Structure
PDB | 1FDO |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | Escherichia |
Primary Citation |
Crystal structure of formate dehydrogenase H: catalysis involving Mo, molybdopterin, selenocysteine, and an Fe4S4 cluster.
Science
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