CATH Domain 1fd9A01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.10	Roll
	3.10.50	Chitinase A; domain 3
	3.10.50.40

Domain Context

CATH Clusters

Superfamily	3.10.50.40
Functional Family

Enzyme Information

5.2.1.8

Peptidylprolyl isomerase.

based on mapping to UniProt Q5ZXE0

Peptidylproline (omega=180) = peptidylproline (omega=0).

-!- The first type of this enzyme found proved to be the protein cyclophilin, which binds the immunosuppressant cyclosporin A. -!- Other distinct families of the enzyme exist, one being FK-506 binding proteins (FKBP) and another that includes parvulin from Escherichia coli. -!- The three families are structurally unrelated and can be distinguished by being inhibited by cyclosporin A, FK-506 and 5-hydroxy-1,4-naphthoquinone, respectively.

UniProtKB Entries (1)

Q5ZXE0

MIP_LEGPH

Legionella pneumophila subsp. pneumophila str. Philadelphia 1

Outer membrane protein MIP

PDB Structure

PDB	1FD9
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Crystal structure of Mip, a prolylisomerase from Legionella pneumophila Riboldi-Tunnicliffe, A., Konig, B., Jessen, S., Weiss, M.S., Rahfeld, J., Hacker, J., Fischer, G., Hilgenfeld, R. Nat.Struct.Biol.