CATH Domain 1f8mC00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.20	Alpha-Beta Barrel
	3.20.20	TIM Barrel
	3.20.20.60	Phosphoenolpyruvate-binding domains

Domain Context

CATH Clusters

Superfamily	Phosphoenolpyruvate-binding domains
Functional Family	Isocitrate lyase

Enzyme Information

4.1.3.30	Methylisocitrate lyase. based on mapping to UniProt P9WKK7 (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate. -!- Acts on threo-D(s)-2-methylisocitrate, but not on threo-D(s)- isocitrate, threo-DL-isocitrate or erythro-L(s)-isocitrate.
4.1.3.1	Isocitrate lyase. based on mapping to UniProt P9WKK7 Isocitrate = succinate + glyoxylate. -!- The isomer of isocitrate involved is (1R,2S)-1-hydroxypropane-1,2,3- tricarboxylate.

UniProtKB Entries (1)

ACEA_MYCTU

Mycobacterium tuberculosis H37Rv

Isocitrate lyase

PDB Structure

PDB	1F8M
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Structure of isocitrate lyase, a persistence factor of Mycobacterium tuberculosis. Sharma, V., Sharma, S., Hoener zu Bentrup, K., McKinney, J.D., Russell, D.G., Jacobs Jr., W.R., Sacchettini, J.C. Nat.Struct.Biol.