CATH Classification

Domain Context

CATH Clusters

Superfamily Laminin
Functional Family Coagulation factor VII

Enzyme Information

3.4.21.21
Coagulation factor VIIa.
based on mapping to UniProt P08709
Selective cleavage of Arg-|-Ile bond in factor X to form factor Xa.
-!- Formed from the precursor factor VII. -!- The cattle enzyme is more readily inhibited by diisopropyl fluorophosphate than the human. -!- Belongs to peptidase family S1.

UniProtKB Entries (1)

P08709
FA7_HUMAN
Homo sapiens
Coagulation factor VII

PDB Structure

PDB 1F7E
External Links
Method SOLUTION NMR
Organism Escherichia
Primary Citation
The effect of O-fucosylation on the first EGF-like domain from human blood coagulation factor VII.
Kao, Y.H., Lee, G.F., Wang, Y., Starovasnik, M.A., Kelley, R.F., Spellman, M.W., Lerner, L.
Biochemistry