CATH Domain 1evzA02

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.1040	N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2
	1.10.1040.10	N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2

Superfamily	N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2
Functional Family	Glycerol-3-phosphate dehydrogenase [NAD(P)+]

1.1.1.8

Glycerol-3-phosphate dehydrogenase (NAD(+)).

based on mapping to UniProt P90551

sn-glycerol 3-phosphate + NAD(+) = glycerone phosphate + NADH.

-!- Also acts on propane-1,2-diol phosphate and glycerone sulfate (but with a much lower affinity).

GPDA_LEIME

Leishmania mexicana

Glycerol-3-phosphate dehydrogenase [NAD(+)], glycosomal

PDB	1EVZ
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	A potential target enzyme for trypanocidal drugs revealed by the crystal structure of NAD-dependent glycerol-3-phosphate dehydrogenase from Leishmania mexicana. Suresh, S., Turley, S., Opperdoes, F.R., Michels, P.A., Hol, W.G. Structure Fold.Des.