CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.720 | NAD(P)-binding Rossmann-like Domain |
Domain Context
CATH Clusters
| Superfamily | NAD(P)-binding Rossmann-like Domain |
| Functional Family |
Enzyme Information
| 1.1.99.28 |
Glucose-fructose oxidoreductase.
based on mapping to UniProt Q07982
D-glucose + D-fructose = D-gluconolactone + D-glucitol.
-!- D-mannose, D-xylose, D-galactose, 2-deoxy-D-glucose and L-arabinose will function as aldose substrates, but with low affinities. -!- The ketose substrate must be in the open-chain form. -!- The apparent affinity for fructose is low, because little of the fructose substrate is in the open-chain form. -!- Xylulose and glycerone (dihydroxyacetone) will replace fructose, but they are poor substrates. -!- The enzyme from Zymomonas mobilis contains tightly bound NADP(+).
|
UniProtKB Entries (1)
| Q07982 |
GFO_ZYMMO
Zymomonas mobilis subsp. mobilis ZM4 = ATCC 31821
Glucose--fructose oxidoreductase
|
PDB Structure
| PDB | 1EVJ |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Zymomonas |
| Primary Citation |
Crystal structure of a truncated mutant of glucose-fructose oxidoreductase shows that an N-terminal arm controls tetramer formation.
J.Mol.Biol.
|