CATH Domain 1evjA02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.360	Dihydrodipicolinate Reductase; domain 2
	3.30.360.10	Dihydrodipicolinate Reductase; domain 2

Domain Context

CATH Clusters

Superfamily	Dihydrodipicolinate Reductase; domain 2
Functional Family

Enzyme Information

1.1.99.28

Glucose-fructose oxidoreductase.

based on mapping to UniProt Q07982

D-glucose + D-fructose = D-gluconolactone + D-glucitol.

-!- D-mannose, D-xylose, D-galactose, 2-deoxy-D-glucose and L-arabinose will function as aldose substrates, but with low affinities. -!- The ketose substrate must be in the open-chain form. -!- The apparent affinity for fructose is low, because little of the fructose substrate is in the open-chain form. -!- Xylulose and glycerone (dihydroxyacetone) will replace fructose, but they are poor substrates. -!- The enzyme from Zymomonas mobilis contains tightly bound NADP(+).

UniProtKB Entries (1)

Q07982

GFO_ZYMMO

Zymomonas mobilis subsp. mobilis ZM4 = ATCC 31821

Glucose--fructose oxidoreductase

PDB Structure

PDB	1EVJ
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Zymomonas
Primary Citation	Crystal structure of a truncated mutant of glucose-fructose oxidoreductase shows that an N-terminal arm controls tetramer formation. Lott, J.S., Halbig, D., Baker, H.M., Hardman, M.J., Sprenger, G.A., Baker, E.N. J.Mol.Biol.