CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.20 | Alpha-Beta Barrel |
|
3.20.20 | TIM Barrel |
|
3.20.20.70 | Aldolase class I |
Domain Context
CATH Clusters
| Superfamily | Aldolase class I |
| Functional Family | KHG/KDPG aldolase |
Enzyme Information
| 4.1.3.16 |
4-hydroxy-2-oxoglutarate aldolase.
based on mapping to UniProt A0A140NB38
4-hydroxy-2-oxoglutarate = pyruvate + glyoxylate.
-!- The enzymes from rat liver and bovine liver act on both enantiomers of 4-hydroxy-2-oxoglutarate. -!- Formerly EC 4.1.2.1 and EC 4.1.2.31.
|
| 4.1.2.14 |
2-dehydro-3-deoxy-phosphogluconate aldolase.
based on mapping to UniProt A0A140NB38
2-dehydro-3-deoxy-6-phosphate-D-gluconate = pyruvate + D-glyceraldehyde 3-phosphate.
-!- The enzyme shows no activity with 2-dehydro-3-deoxy-6-phosphate-D- galactonate (cf. EC 4.1.2.55). -!- Also acts on 2-oxobutanoate.
|
UniProtKB Entries (1)
| A0A140NB38 |
A0A140NB38_ECOBD
Escherichia coli BL21(DE3)
2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase
|
PDB Structure
| PDB | 1EUA |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Covalent intermediate trapped in 2-keto-3-deoxy-6- phosphogluconate (KDPG) aldolase structure at 1.95-A resolution.
Proc.Natl.Acad.Sci.USA
|
