CATH Domain 1efyA02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.228	Phosphoenolpyruvate Carboxykinase; domain 3
	3.90.228.10

Domain Context

CATH Clusters

Superfamily	3.90.228.10
Functional Family	Poly [ADP-ribose] polymerase

Enzyme Information

2.4.2.30

NAD(+) ADP-ribosyltransferase.

based on mapping to UniProt P26446

NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D- ribosyl)(n+1)-acceptor.

-!- The ADP-D-ribosyl group of NAD(+) is transferred to an acceptor carboxy group on a histone or the enzyme itself, and further ADP- ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units.

2.4.2.-

Pentosyltransferases.

based on mapping to UniProt P26446

UniProtKB Entries (1)

P26446

PARP1_CHICK

Gallus gallus

Poly [ADP-ribose] polymerase 1

PDB Structure

PDB	1EFY
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Spodoptera
Primary Citation	Resistance-modifying agents. 9. Synthesis and biological properties of benzimidazole inhibitors of the DNA repair enzyme poly(ADP-ribose) polymerase. White, A.W., Almassy, R., Calvert, A.H., Curtin, N.J., Griffin, R.J., Hostomsky, Z., Maegley, K., Newell, D.R., Srinivasan, S., Golding, B.T. J.Med.Chem.