CATH Classification

Domain Context

CATH Clusters

Superfamily Haem peroxidase domain superfamily, animal type
Functional Family Prostaglandin G/H synthase 2

Enzyme Information

1.14.99.1
Prostaglandin-endoperoxide synthase.
based on mapping to UniProt P05979
Arachidonate + AH(2) + 2 O(2) = prostaglandin H(2) + A + H(2)O.
-!- Acts both as a dioxygenase and as a peroxidase.

UniProtKB Entries (1)

P05979
PGH1_SHEEP
Ovis aries
Prostaglandin G/H synthase 1

PDB Structure

PDB 1EBV
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
O-acetylsalicylhydroxamic acid, a novel acetylating inhibitor of prostaglandin H2 synthase: structural and functional characterization of enzyme-inhibitor interactions.
Loll, P.J., Sharkey, C.T., O'Connor, S.J., Dooley, C.M., O'Brien, E., Devocelle, M., Nolan, K.B., Selinsky, B.S., Fitzgerald, D.J.
Mol.Pharmacol.
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