CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
2 | Mainly Beta |
|
2.60 | Sandwich |
|
2.60.40 | Immunoglobulin-like |
|
2.60.40.150 | C2 domain |
Domain Context
CATH Clusters
| Superfamily | C2 domain |
| Functional Family | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform |
Enzyme Information
| 2.7.11.1 |
Non-specific serine/threonine protein kinase.
based on mapping to UniProt O02697
ATP + a protein = ADP + a phosphoprotein.
-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.
|
| 2.7.1.153 |
Phosphatidylinositol-4,5-bisphosphate 3-kinase.
based on mapping to UniProt O02697
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate.
-!- This enzyme also catalyzes the phosphorylation of PtdIns4P to PtdIns(3,4)P(2), and of PtdIns to PtdIns3P.
|
UniProtKB Entries (1)
| O02697 |
PK3CG_PIG
Sus scrofa
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
|
PDB Structure
| PDB | 1E8W |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structural Determinations of Phosphoinositide 3-Kinase Inhibition by Wortmannin, Ly294002, Quercetin, Myricetin and Staurosporine
Mol.Cell
|
