CATH Domain 1e8kA00

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.40	Beta Barrel
	2.40.100	Cyclophilin
	2.40.100.10	Cyclophilin-like

Domain Context

CATH Clusters

Superfamily	Cyclophilin-like
Functional Family	Peptidyl-prolyl cis-trans isomerase

Enzyme Information

5.2.1.8

Peptidylprolyl isomerase.

based on mapping to UniProt P52011

Peptidylproline (omega=180) = peptidylproline (omega=0).

-!- The first type of this enzyme found proved to be the protein cyclophilin, which binds the immunosuppressant cyclosporin A. -!- Other distinct families of the enzyme exist, one being FK-506 binding proteins (FKBP) and another that includes parvulin from Escherichia coli. -!- The three families are structurally unrelated and can be distinguished by being inhibited by cyclosporin A, FK-506 and 5-hydroxy-1,4-naphthoquinone, respectively.

UniProtKB Entries (1)

P52011

CYP3_CAEEL

Caenorhabditis elegans

Peptidyl-prolyl cis-trans isomerase 3

PDB Structure

PDB	1E8K
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	The First Direct Determination of a Ligand Binding Constant in Protein Crystals Wu Sy, S.Y., Dornan, J., Kontopidis, G., Taylor, P., Walkinshaw, M.D. Angew.Chem.Int.Ed.Engl.