CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.720 | NAD(P)-binding Rossmann-like Domain |
Domain Context
CATH Clusters
| Superfamily | NAD(P)-binding Rossmann-like Domain |
| Functional Family |
Enzyme Information
| 1.1.1.363 |
Glucose-6-phosphate dehydrogenase (NAD(P)(+)).
based on mapping to UniProt P11411
D-glucose 6-phosphate + NAD(P)(+) = 6-phospho-D-glucono-1,5-lactone + NAD(P)H.
-!- The enzyme catalyzes a step of the pentose phosphate pathway. -!- The enzyme from the Gram-positive bacterium Leuconostoc mesenteroides prefers NADP(+) while the enzyme from the Gram-negative bacterium Gluconacetobacter xylinus prefers NAD(+). -!- Cf. EC 1.1.1.49 and EC 1.1.1.388.
|
UniProtKB Entries (1)
| P11411 |
G6PD_LEUME
Leuconostoc mesenteroides
Glucose-6-phosphate 1-dehydrogenase
|
PDB Structure
| PDB | 1E7Y |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
An Examination of the Role of Asp-177 in the His-Asp Catalytic Dyad of Leuconostoc Mesenteroides Glucose 6-Phosphate Dehydrogenase: X-Ray Structure and Ph Dependence of Kinetic Parameters of the D177N Mutant Enzyme
Biochemistry
|
