CATH Domain 1e6wB00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.720	NAD(P)-binding Rossmann-like Domain

Domain Context

CATH Clusters

Superfamily	NAD(P)-binding Rossmann-like Domain
Functional Family	3-hydroxyacyl-CoA dehydrogenase type-2

Enzyme Information

1.1.1.178	3-hydroxy-2-methylbutyryl-CoA dehydrogenase. based on mapping to UniProt O70351 (2S,3S)-3-hydroxy-2-methylbutanoyl-CoA + NAD(+) = 2-methylacetoacetyl-CoA + NADH. -!- Also acts, more slowly, on (2S,3S)-2-hydroxy-3-methylpentanoyl-CoA.
1.1.1.51	3(or 17)-beta-hydroxysteroid dehydrogenase. based on mapping to UniProt O70351 Testosterone + NAD(P)(+) = androst-4-ene-3,17-dione + NAD(P)H. -!- Also acts on other 3-beta- or 17-beta-hydroxysteroids (cf. EC 1.1.1.209).
1.1.1.35	3-hydroxyacyl-CoA dehydrogenase. based on mapping to UniProt O70351 (S)-3-hydroxyacyl-CoA + NAD(+) = 3-oxoacyl-CoA + NADH. -!- Also oxidizes S-3-hydroxyacyl-N-acylthioethanolamine and S-3- hydroxyacylhydrolipoate. -!- Some enzymes act, more slowly, with NADP(+). -!- Broad specificity to acyl chain-length (cf. EC 1.1.1.211).

UniProtKB Entries (1)

HCD2_RAT

Rattus norvegicus

3-hydroxyacyl-CoA dehydrogenase type-2

PDB Structure

PDB	1E6W
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Recognition of Structurally Diverse Substrates by Type II 3-Hydroxyacyl-Coa Dehydrogenase (Hadh II) Amyloid-Beta Binding Alcohol Dehydrogenase (Abad) Powell, A.J., Read, J.A., Banfield, M.J., Gunn-Moore, F., Yan, S.D., Lustbader, J., Stern, A.R., Stern, D.M., Brady, R.L. J.Mol.Biol.