CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.10 | Orthogonal Bundle |
|
1.10.1720 | Proline Oxidase; Chain: A, Domain 2 |
|
1.10.1720.10 | L-proline 3-hydroxylase, C-terminal domain |
Domain Context
CATH Clusters
| Superfamily | L-proline 3-hydroxylase, C-terminal domain |
| Functional Family |
Enzyme Information
| 1.14.11.28 |
Proline 3-hydroxylase.
based on mapping to UniProt O09345
L-proline + 2-oxoglutarate + O(2) = cis-3-hydroxy-L-proline + succinate + CO(2).
-!- Unlike the proline hydroxylases involved in collagen biosynthesis (EC 1.14.11.2 and EC 1.14.11.7), this enzyme does not require ascorbate for activity although it does increase the activity of the enzyme. -!- The enzyme is specific for L-proline as D-proline, trans-4-hydroxy-L- proline, cis-4-hydroxy-L-proline and 3,4-dehydro-DL-proline are not substrates.
|
UniProtKB Entries (1)
| O09345 |
P3H2_STRSQ
Streptomyces sp.
L-proline cis-3-hydroxylase 2
|
PDB Structure
| PDB | 1E5S |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structure of proline 3-hydroxylase. Evolution of the family of 2-oxoglutarate dependent oxygenases.
Eur.J.Biochem.
|