CATH Classification
Level | CATH Code | Description |
---|---|---|
3 | Alpha Beta | |
3.30 | 2-Layer Sandwich | |
3.30.1490 | Dna Ligase; domain 1 | |
3.30.1490.20 | ATP-grasp fold, A domain |
Domain Context
CATH Clusters
Superfamily | ATP-grasp fold, A domain |
Functional Family | D-alanine--D-alanine ligase |
Enzyme Information
6.1.2.1 |
D-alanine--(R)-lactate ligase.
based on mapping to UniProt P25051
D-alanine + (R)-lactate + ATP = D-alanyl-(R)-lactate + ADP + phosphate.
-!- The product of this enzyme, the depsipeptide D-alanyl-(R)-lactate, can be incorporated into the peptidoglycan pentapeptide instead of the usual D-alanyl-D-alanine dipeptide, which is formed by EC 6.3.2.4. -!- The resulting peptidoglycan does not bind the glycopeptide antibiotics vancomycin and teicoplanin, conferring resistance on the bacteria.
|
UniProtKB Entries (1)
P25051 |
VANA_ENTFC
Enterococcus faecium
Vancomycin/teicoplanin A-type resistance protein VanA
|
PDB Structure
PDB | 1E4E |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
The molecular basis of vancomycin resistance in clinically relevant Enterococci: crystal structure of D-alanyl-D-lactate ligase (VanA).
Proc. Natl. Acad. Sci. U.S.A.
|