CATH Classification

Domain Context

CATH Clusters

Superfamily Flavocytochrome C3; Chain A
Functional Family Fumarate reductase flavoprotein subunit

Enzyme Information

1.3.5.4
Fumarate reductase (quinol).
based on mapping to UniProt P0C278
Succinate + a quinone = fumarate + a quinol.
-!- The enzyme, which is found in anaerobic and facultative organisms such as bacteria, parasitic helminthes, and lower marine organisms, utilizes low potential quinols, such as menaquinol and rhodoquinol, to reduce fumarate as the final step of an anaerobic respiratory chain. -!- The enzyme is known as complex II of the electron transfer chain, similarly to EC 1.3.5.1, to which it is closely related.

UniProtKB Entries (1)

P0C278
FRDA_SHEFR
Shewanella frigidimarina
Fumarate reductase flavoprotein subunit

PDB Structure

PDB 1E39
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Identification of the Active Site Acid/Base Catalyst in a Bacterial Fumarate Reductase: A Kinetic and Crystallographic Study
Doherty, M.K., Pealing, S.L., Miles, C.S., Moysey, R., Taylor, P., Walkinshaw, M.D., Reid, G.A., Chapman, S.K.
Biochemistry