CATH Classification

Domain Context

CATH Clusters

Superfamily Cyclophilin-like
Functional Family Peptidyl-prolyl cis-trans isomerase

Enzyme Information

5.2.1.8
Peptidylprolyl isomerase.
based on mapping to UniProt P52011
Peptidylproline (omega=180) = peptidylproline (omega=0).
-!- The first type of this enzyme found proved to be the protein cyclophilin, which binds the immunosuppressant cyclosporin A. -!- Other distinct families of the enzyme exist, one being FK-506 binding proteins (FKBP) and another that includes parvulin from Escherichia coli. -!- The three families are structurally unrelated and can be distinguished by being inhibited by cyclosporin A, FK-506 and 5-hydroxy-1,4-naphthoquinone, respectively.

UniProtKB Entries (1)

P52011
CYP3_CAEEL
Caenorhabditis elegans
Peptidyl-prolyl cis-trans isomerase 3

PDB Structure

PDB 1DYW
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Biochemical and Structural Characterization of a Divergent Loop Cyclophilin from Caenorhabditis Elegans
Dornan, J., Page, A.P., Taylor, P., Wu, S.Y., Winter, A.D., Husi, H., Walkinshaw, M.D.
J.Biol.Chem.