CATH Domain 1dquA01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.20	Alpha-Beta Barrel
	3.20.20	TIM Barrel
	3.20.20.60	Phosphoenolpyruvate-binding domains

Domain Context

CATH Clusters

Superfamily	Phosphoenolpyruvate-binding domains
Functional Family	Isocitrate lyase

Enzyme Information

4.1.3.30	Methylisocitrate lyase. based on mapping to UniProt P28298 (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate. -!- Acts on threo-D(s)-2-methylisocitrate, but not on threo-D(s)- isocitrate, threo-DL-isocitrate or erythro-L(s)-isocitrate.
4.1.3.1	Isocitrate lyase. based on mapping to UniProt P28298 Isocitrate = succinate + glyoxylate. -!- The isomer of isocitrate involved is (1R,2S)-1-hydroxypropane-1,2,3- tricarboxylate.

UniProtKB Entries (1)

ACEA_EMENI

Aspergillus nidulans FGSC A4

Isocitrate lyase

PDB Structure

PDB	1DQU
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Emericella
Primary Citation	The crystal structure and active site location of isocitrate lyase from the fungus Aspergillus nidulans. Britton, K., Langridge, S., Baker, P.J., Weeradechapon, K., Sedelnikova, S.E., De Lucas, J.R., Rice, D.W., Turner, G. Structure Fold.Des.