CATH Domain 1dilA00

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.120	6 Propeller
	2.120.10	Neuraminidase
	2.120.10.10

Domain Context

CATH Clusters

Superfamily	2.120.10.10
Functional Family	Sialidase

Enzyme Information

3.2.1.18

Exo-alpha-sialidase.

based on mapping to UniProt P29768

Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.

-!- The enzyme does not act on 4-O-acetylated sialic acids. -!- An endo-alpha-sialidase activity is listed as EC 3.2.1.129. -!- See also EC 4.2.2.15.

UniProtKB Entries (1)

P29768

NANH_SALTY

Salmonella enterica subsp. enterica serovar Typhimurium str. LT2

Sialidase

PDB Structure

PDB	1DIL
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	The structures of Salmonella typhimurium LT2 neuraminidase and its complexes with three inhibitors at high resolution. Crennell, S.J., Garman, E.F., Philippon, C., Vasella, A., Laver, W.G., Vimr, E.R., Taylor, G.L. J.Mol.Biol.