CATH Classification
Level | CATH Code | Description |
---|---|---|
3 | Alpha Beta | |
3.30 | 2-Layer Sandwich | |
3.30.360 | Dihydrodipicolinate Reductase; domain 2 | |
3.30.360.10 | Dihydrodipicolinate Reductase; domain 2 |
Domain Context
CATH Clusters
Superfamily | Dihydrodipicolinate Reductase; domain 2 |
Functional Family | 4-hydroxy-tetrahydrodipicolinate reductase |
Enzyme Information
1.17.1.8 |
4-hydroxy-tetrahydrodipicolinate reductase.
based on mapping to UniProt P04036
(S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD(P)(+) + H(2)O = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD(P)H.
-!- Studies of the enzyme from the bacterium Escherichia coli have shown that the enzyme accepts (2S,4S)-4-hydroxy-2,3,4,5- tetrahydrodipicolinate and not (S)-2,3-dihydrodipicolinate as originally thought. -!- Formerly EC 1.3.1.26.
|
UniProtKB Entries (1)
P04036 |
DAPB_ECOLI
Escherichia coli K-12
4-hydroxy-tetrahydrodipicolinate reductase
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PDB Structure
PDB | 1DIH |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | Escherichia |
Primary Citation |
Three-dimensional structure of Escherichia coli dihydrodipicolinate reductase.
Biochemistry
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